Concepts in Chemical Biology

6 EC

Semester 2, period 5

5254CICB6Y

Owner Master Chemistry (joint degree)
Coordinator T.N. Grossmann
Part of Master Chemistry (joint degree), track Analytical Sciences, Master Chemistry (joint degree), track Molecular Sciences, Master Chemistry (joint degree), track Science for Energy and Sustainability,

Course manual 2019/2020

Objectives

  • Attain the ability to critically discuss published data
  • Know the hallmarks of cancer and know the underlying principles
  • Know core cancer signaling pathways
  • Know inhibition strategies of signaling pathways – e.g. use of small molecules, stabilized peptides
  • Know peptidomimetics and their use for challenging targets in signaling pathways
  • Know chemical reactions for the selective covalent modification of proteins
  • Know protein labeling techniques (encoded tags, enzymes (PTMs), reactions)
  • Know bio-orthogonal and ligand directed reactions
  • Know (non-)natural protein modifications for improved functions
  • Know classical protein engineering (natural: directed evolution, disulfide…)
  • Know principle idea of pluripotency vs. induced pluripotency (Yamanaka factors)
  • Know features of iPS and iPS generation
  • Know chemical modulation of stem cell differentiation

Learning activities

Activity

Hours

Deeltoets

3

Hoorcollege

19.25

Tentamen

5.5

Self study

140.25

Total

168

(6 EC x 28 uur)

Attendance

This programme does not have requirements concerning attendance (TER part B).

Assessment

Item and weight Details

Final grade

1 (25%)

Assignment 01 - Hallmarks of Cancer

Must be ≥ 5.5, Mandatory

1 (25%)

Assignment 02 - Visualization of Proteins

Must be ≥ 5.5, Mandatory

1 (25%)

Assignment 03

Must be ≥ 5.5, Mandatory

1 (25%)

Assignment 04

Must be ≥ 5.5, Mandatory

Fraud and plagiarism

The 'Regulations governing fraud and plagiarism for UvA students' applies to this course. This will be monitored carefully. Upon suspicion of fraud or plagiarism the Examinations Board of the programme will be informed. For the 'Regulations governing fraud and plagiarism for UvA students' see: www.student.uva.nl

Course structure

WeeknummerOnderwerpenStudiestof
1
2
3
4
5
6
7
8

Contact information

Coordinator

  • T.N. Grossmann