Advanced Immunology

6 EC

Semester 1, period 1

5234ADIM6Y

Owner Master Biomedical Sciences
Coordinator prof. dr. S.M. van Ham
Part of Master Biomedical Sciences, track Infection and Immunity,

Course manual 2019/2020

Course content

In this course, students learn from and interact with scientists actively working in various areas of immunology. Starting from the textbook Immunobiology of Janeway, main immunology themes will be presented by staff scientists of the two participating institutes (AMC and Sanquin). In 2-day cycles, they will address a theme (e.g. macrophages and pattern recognition) in a morning lecture session (3 hrs) that will work towards 1 or 2 contemporary articles in that field. The articles will be posted on CANVAS in advance. The afternoon the students will read the article(s) which will be presented by selected students and discussed by all during an interactive tutorial session (article presentations and pitches) the next morning(3 hrs). The afternoon that follows, time is reserved to prepare the textbook study material and possibly articles for the next 2-day cycle. The courses thus consists of 9 cycles of lectures and workdiscussion sessions. In addition, 1 or 2 mornings will be reserved for lectures that discuss the use and applicabilities of the state-of-the-art immunological techniques that you are likely to apply during internships. The course is intense and will provide a fast learning curve at Master level education.

Study materials

Literature

  • Immunobiology (Janeway et al., 9th edition)

Syllabus

  • PDFs of articles on CANVAS

Objectives

  • At the end of the course, the student will have a throrough knowlegde of state-of-the-art immunological principles
  • At the end of the course, the student will have enough knowlegde about state-of-the-art techniques to be able to choose the appropiate techniques for specific research questions during internships and to execute the technique and interpret data.
  • At the end of the course, the student is able to read and interpret current research articles in immunology.
  • At the end of the course, the student is able to present data from a research article
  • At the end of the course the student will be able to receive and give feedback on contents and execution of scientific presentations.

Teaching methods

  • Lecture
  • Presentation/symposium
  • Self-study
  • Supervision/feedback meeting
Lecture sessions25%
Reading Articles, preparing presentation50%
Presentations by students + discussion25%

Learning activities

Activity

Number of hours

Hoorcollege

80

Zelfstudie

88

Attendance

This programme does not have requirements concerning attendance (TER part B).

Additional requirements for this course:

The student may be absent 1 time maximally.

Absence needs to be communicate to the one of the two course coordinators (Eldering/van Ham.

Assessment

Item and weight Details Remarks

Final grade

Final grade is made of 1/3 of each grade of: 1) average of Janeway tests, 2) paper tests and 3) presentations

Fraud and plagiarism

The 'Regulations governing fraud and plagiarism for UvA students' applies to this course. This will be monitored carefully. Upon suspicion of fraud or plagiarism the Examinations Board of the programme will be informed. For the 'Regulations governing fraud and plagiarism for UvA students' see: www.student.uva.nl

Course structure

  date from untill teacher location room study material for test subject
              paragraphs/pages of Janeway, 9th edition  
Monday 30-sep 9:30 12:30 Marieke van Ham (& PhD student Casper Marsman) SANQUIN Auditorium   Introduction into course and track
Tuesday 1-okt 9:30 12:30 Anja ten Brinke SANQUIN Auditorium   Current research assays in immunology
Wednesday 2-okt 9:30 12:30 Ilse Jongerius SANQUIN Auditorium 2-5 uti (= up to and included) 2-16 Innate immunity:
Thursday 3-okt 9:30 12:30 Ilse Jongerius SANQUIN D-053   Complement and phagocytosis
Friday 4-okt 9:30 12:30 Esther de Jong SANQUIN D-053 9.8, 9.10, 9.15, 9.17, 9.18, 9.19, 9.20, 9.21, 9.22, 9.23, 9.26, 9.27, 11.5, 11.9, 11.10 Dendritic cells in immunity and tolerance
Saturday 5-okt              
Sunday 6-okt              
Monday 7-okt 9:30 12:30 Esther de Jong SANQUIN Auditorium    
Tuesday 8-okt 9:30 12:30 Derk Amsen SANQUIN D-053 11-5 uti 11-10/ 11-17 uti 11-24 Cell fate determination in immunity
Wednesday 9-okt 9:30 12:30 Derk Amsen SANQUIN B-108    
Thursday 10-okt 9:30 12:30 Bianca Blom SANQUIN D-053 p. 126-127, p. 493-496 until 12-2, 12-3 until 12-5, p. 503-512 (12-7 uti fig. 12.14), 12-16 uti 12-22 Mucosal Immunity and
Friday 11-okt 9:30 12:30 Bianca Blom SANQUIN Auditorium   Innate Lymphoid Cells
Saturday 12-okt              
Sunday 13-okt              
Monday 14-okt 9:30 12:30 Marieke van Ham AMC HvA, room D1.30 6-1/ 6-3 uti 6-8/ 11-18 uti 11-19/ 13-23 Antigen presentation and immune
Tuesday 15-okt 9:30 12:30 Marieke van Ham AMC HvA, room D1.30   regulation through B/T cell interactions
Wednesday 16-okt 9:30 12:30 Eric Eldering AMC HvA, room D1.30 4-1 uti 4-9/ 5-1 uti 5-4 B cells, antibodies, affinity & apoptosis
Thursday 17-okt 9:30 12:30 Eric Eldering AMC HvA, room D1.30    
Friday 18-okt 9:30 12:30 Martijn Nolte AMC HvA, room D1.30 9.1/ 9.3 uti 9.7/ 9.18/ 11.3/ 11.21/ 11.22 T cell homing and activation
Saturday 19-okt              
Sunday 20-okt              
Monday 21-okt 9:30 12:30 Martijn Nolte AMC HvA, room D1.30    
Tuesday 22-okt 9:30 12:30 Robin van Bruggen AMC HvA, room D1.30 13-3 tm 13-15 Failures of host defense mechanisms &
Wednesday 23-okt 9:30 12:30 Robin van Bruggen AMC HvA, room D1.30   Evolution of the immune system
Thursday 24-okt 9:30 12:30 René Lutter AMC HvA, room D1.30 p. 601 until 14.2/ p. 612 until 14.10/ 14.14 until 14.7 Inflammation & Allergy
Friday 25-okt 9:30 12:30 René Lutter + Marieke van Ham AMC HvA, room D1.30   Course evaluation

Timetable

The schedule for this course is published on DataNose.

Additional information

Location: Sanquin and AMC.

Basic knowledge of immunology as well as understanding of selected chapters of the textbook Janeway's Immunobiology by Murphy, Travers and Walport, 8th edition (chapters will be posted on blackboard after registration for the course).

The maximum number of students is 25. Admission to the course will depend on the capacity, the total number of applications, the date of registration and background of the individual student. If the number of applications exceeds the capacity of the course, student may have to be selected and priority will be given, in the following order:

  • first-year students of the track Infection & Immunity
  • second-year students of the track Infection & Immunity
  • master students of the Medical Biology cluster (Biomedical Sciences)
  • master students of other master programmes

Contact information

Coordinator

  • prof. dr. S.M. van Ham