6 EC
Semester 1, period 1
5234BISB6Y
| Owner | Master Biomedical Sciences |
| Coordinator | prof. dr. S. Brul |
| Part of | Master Biomedical Sciences, track Biochemistry and Metabolic Diseases, year 1 |
In the course Biomedical Systems Biology the teachers will introduce you to a thorough understanding of how molecules interact in cellular systems and thus determine important chemical and cellular processes that occur during health and disease. The recurrent theme is the integrative analysis of stress response in biology where genetic, signal transduction and metabolic reactions form an integrated complex network of spatially and temporally resolved interactions that strive to homeostasis in response to environmental perturbations. The approach reflects the focus on Systems Biology that the course takes and that is in-line with the research done in the masters program as a whole. We offer different biomedical research challenges for the students to work on. These are the development of insight in personalised medicine and cell division (cancer) regulation, stems-cell biology, modelorganisms in Biomedical science, the development of novel antibiotics to cure infection as well as leads for antimicrobials relevant to microbial food safety, the microbiome and human health. By the end of week 2 key-note lectures provide perspectives of how contemporary biomedical topics are studied with systems biology approaches and a computer practical is taught.New this year is the introduction of more chemical tools such as proteomics, an introduction to enzyme catalysis as well as bio-inspired organic synthesis.
Week 1: Biological systems: from microbes to modelorganisms & man
Week 2: Systems Biology tools & techniques
Week 3: Towards a research proposal
Week 4: Finalizing research proposal and examination
The combination of courses in Biomedical Systems Biology and Biotechnology is intended to give students a full apprehension of both the theoretical background and practical application of clinically relevant biochemical and molecular biological research.
Molecular Biology of the Cell, Alberts et al., Taylor & Francis Inc (6th ed.)
Copasi (available at the course)
After the course students;
|
Activity |
Number of hours |
|
Tutorials |
6 |
|
Lectures |
30 |
|
Assignment (mainly as unsupervised group work) |
40 |
|
Symposium (presentation including preparation) |
16 |
|
Exam |
3 |
|
Question hour |
2 |
|
Self study |
71 |
|
Total 6 x 28 h |
168 |
The programme does not have requirements concerning attendance (OER-B).
Additional requirements for this course:
The lectures are all crucial so also those on the topics that you will not work on! Examination questions may be drawn from any of the topics presented in the first week. Attendance of the lectures in the second week is to familiarise yourself with the technological possibilities!
| Item and weight | Details |
|
Final grade | |
|
50% Tentamen | |
|
50% Research Proposal |
The date, time and location of the inspection moment are in the DataNose timetable.
The Assignment involves the evaluation of a research proposal; an oral presentation and the assessment and discussion of a proposal of fellow students is a formative assignment.
The 'Regulations governing fraud and plagiarism for UvA students' applies to this course. This will be monitored carefully. Upon suspicion of fraud or plagiarism the Examinations Board of the programme will be informed. For the 'Regulations governing fraud and plagiarism for UvA students' see: www.student.uva.nl
| Weeknummer | Onderwerpen | Studiestof |
| 1 | Topics for assignments & individual test | lecture hand-outs & assignment explanation |
| 2 | Tools to work on the assignments (couples) | lecture hand-outs & computer practical |
| 3 | Work on the assignment & presentation | NWO-Open Competition project structure |
| 4 | finalize assignment & individual examination (open book) | |
| 5 | ||
| 6 | ||
| 7 | ||
| 8 |
The schedule for this course is published on DataNose.