Nuclear Magnetic Resonance

Course manual 2017/2018

Course content

Global content

The course aims at providing students insight in the principles of one- and twodimensional high-resolution NMR spectroscopy with an emphasis on methods, techniques and their applications in synthetic chemistry. A brief rehearsal of basic principles of NMR spectroscopy is followed by methods of obtaining spectra of most NMR-active nuclei by means of standard excitation and detection schemes. Some necessary background of principles will be provided. Most of the standard and several non-standard one- and two-dimensional NMR techniques will be treated.

Subjects

Physical basis, principles, pulsed NMR, chemical shift, spin-spin and dipolar coupling, relaxation, nuclear Overhauser enhancement, multi-puls NMR (spin-echo, J-modulated, polarization transfer, INEPT, DEPT), vector models for selected pulse sequences, common and less common nuclei, two-dimensional NMR (COSY, HETCOR, HSQC, HMQC, HMBC, TOCSY, INADEQUATE), spectrum analyisis, assignment of 1D and 2D spectra, dynamic NMR.

Study materials

Literature

• H. Friebolin, 'Basic One- and Two-Dimensional NMR Spectroscopy', 5th ed., Wiley-VCH, 2010.

Other

• Hand-outs.

Objectives

The student; 

• understands the basics of NMR spectroscopy.
• is able to define spin-systems, assign chemical shifts, inspect NMR spectra for (trivial) problems.
• can follow and interpret the outcome of simple pulse sequences on the basis of a vector model for various nuclei.
• is aware of and can apply the most common 1D and 2D NMR techniques, including their application to hetero-nuclei such as 19F, 31P, various metal nuclei.
• is able to assign (complex) spectra of molecules when molecular and/or structural formulae are known. Such spectra may involve heteronuclei such as 10/11B, 14/15N, 19F, 31P, several metal nuclei.
• is able to find the structure of an unknown molecule from a series of NMR spectra
• knows of the most important relaxation processes and how these influence NMR spectra. 
• gains basic understanding of dynamic NMR.
• Student can apply NMR to practice in synthetic organic and organometallic chemistry.

Teaching methods

• Lecture
• Seminar

Lectures and problem sessions.

Learning activities

Attendance

The programme does not have requirements concerning attendance (OER-B).

Assessment

Assignments

Assignments

• Students will be given exercises to do and discuss during class and assignments for preparation outside class; some of these will be treated in the whole group and in the tutoring hours. Special attention will be given to spectrum interpretation and obtaining structures of molecules from a set of spectra

Fraud and plagiarism

The 'Regulations governing fraud and plagiarism for UvA students' applies to this course. This will be monitored carefully. Upon suspicion of fraud or plagiarism the Examinations Board of the programme will be informed. For the 'Regulations governing fraud and plagiarism for UvA students' see: www.student.uva.nl

Course structure

Timetable

The schedule for this course is published on DataNose.

Additional information

Recommended prior knowledge: Bachelor level spectroscopy

Contact information

Coordinator

• prof. dr. C.J. Elsevier