Dynamics of biomolecules and cells

Dynamics of Biomolecules and Cells

6 EC

Semester 2, period 4

53548DYB6Y

Owner Master Physics and Astronomy (joint degree)
Coordinator dr. J.T.M. Kennis
Part of Master Physics and Astronomy, track Physics of Life and Health, year 1

Course manual 2017/2018

Course content

The significance of small movements to large-scale and slow reorganizations are being discussed as well the experimental techniques employed. - DNA processing and dynamics (techniques: optical tweezers, AFM, tethered particle motion, magnetic tweezers). DNA structure and stability, DNA/RNA polymerase, DNA architectural proteins, DNA repair. - Protein dynamics (techniques: ultrafast spectroscopy, Infrared and Raman spectroscopy, single-molecule fluorescence). Photoactive proteins, light-driven enzymes, Motor proteins, optogenetics. - Membrane dynamics and remodeling (techniques AFM, single molecule, electron microscopy). Photosynthesis, crowding and membrane protein diffusion, Neuroimaging. -superresolution microscopy

Objectives

Life is, by its very definition, a dynamic quantity. In this course an overview is given of dynamic processes that take place in biomolecules, membranes and cells in relation to biological functionality, and the biophysical methods that are applied to study them.

Teaching methods

    Learning activities

    Activity

    Hours

    Hoorcollege

    24.5

    Tentamen

    5.5

    Self study

    138

    Total

    168

    (6 EC x 28 uur)

    Attendance

    Requirements concerning attendance (OER-B).

  • In addition to, or instead of, classes in the form of lectures, the elements of the master’s examination programme often include a practical component as defined in article 1.2 of part A. The course catalogue contains information on the types of classes in each part of the programme. Attendance during practical components is mandatory.
  • Assessment

    Item and weight Details

    Final grade

    1 (50%)

    Tentamen 1

    1 (50%)

    Tentamen 2

    Fraud and plagiarism

    The 'Regulations governing fraud and plagiarism for UvA students' applies to this course. This will be monitored carefully. Upon suspicion of fraud or plagiarism the Examinations Board of the programme will be informed. For the 'Regulations governing fraud and plagiarism for UvA students' see: www.student.uva.nl

    Course structure

    WeeknummerOnderwerpenStudiestof
    1
    2
    3
    4
    5
    6
    7
    8

    Contact information

    Coordinator

    • dr. J.T.M. Kennis