Parameter Estimation Applied to Medical & Biological Science

6 EC

Semester 2, period 4

53548PEM6Y

Owner Master Physics and Astronomy (joint degree)
Coordinator dr. J.C. de Munck
Part of Master Physics and Astronomy, track Physics of Life and Health, year 1Master Computational Science (Joint Degree), year 2

Course manual 2017/2018

Course content

Linear-non linear parameter models, basic matrix-vector algebra, maximum likelihood principle, correlated-uncorrelated noise, OLS, GLS, nuisance parameters, linear (time invariant) filters, t-test, F-test, confidence intervals, fMRI data model, missing data, MEG/EEG source localisation. These topics are treated in the form of a series of lectures alternated with exercises. Extra topics: L1 en L2 norms.

Objectives

The course treats the theory of parameter estimation problems in general, but the theory is illustrated extensively by examples from medical and biological sciences and brain imaging (fMRI and MEG/EEG) in particular. Linear and non-linear regression analysis is treated, as well as confidence intervals and significance testing. The goal of the course is to provide insight into the theory of parameter estimation and to develop a critical attitude towards its application and interpretation in order to avoid inconsistent and improper use of the theory.

Teaching methods

  • Lecture
  • Computer lab session/practical training

Learning activities

Activity

Hours

Hoorcollege

33

Practicum

5.5

Tentamen

5.5

Self study

124

Total

168

(6 EC x 28 uur)

Attendance

Requirements concerning attendance (OER-B).

  • In addition to, or instead of, classes in the form of lectures, the elements of the master’s examination programme often include a practical component as defined in article 1.2 of part A. The course catalogue contains information on the types of classes in each part of the programme. Attendance during practical components is mandatory.
  • Assessment

    Item and weight Details

    Final grade

    1 (100%)

    Tentamen 1

    Tentamen 2

    Fraud and plagiarism

    The 'Regulations governing fraud and plagiarism for UvA students' applies to this course. This will be monitored carefully. Upon suspicion of fraud or plagiarism the Examinations Board of the programme will be informed. For the 'Regulations governing fraud and plagiarism for UvA students' see: www.student.uva.nl

    Course structure

    WeeknummerOnderwerpenStudiestof
    1
    2
    3
    4
    5
    6
    7
    8

    Contact information

    Coordinator

    • dr. J.C. de Munck