6 EC
Semester 1, period 1
53541PHO6Y
The human body requires a continuous and well-regulated supply of oxygen to all cells. This is accomplished by the respiratory and circulatory systems, connected in series. Physical aspects such as fluid mechanics, diffusion and elasticity are of primary importance for functioning of these systems. Moreover, such physics play a key role in diseases such as asthma, hypertension and heart failure. Finally, physical principles form the heart of many of the measurements done on the respiratory and circulatory systems in experimental studies and in clinical routine. We will combine physics and physiology in order to improve your understanding of these important systems.
On completion of this course, you understand the functioning of circulation and respiration from a physical point of view. In particular, you should be able to:
Work groups aimed at clarifying the functioning of heart, vessels and lungs. Individual and Group exercises and presentation by students of basic training questions and challenging problems, discussions on current state of this research field.
|
Activity |
Number of hours |
|
First instruction meeting |
4 |
|
11 regular sessions, each: 6 hours preparation 4 hours meeting |
110 |
|
Two round-up sessions, each: 3 hours preparation 4 hours meeting |
14 |
|
Preparation for exam |
35 |
|
Exam |
3 |
|
Total |
166 |
Requirements concerning attendance (OER-B).
| Item and weight | Details | Remarks |
|
Final grade | ||
|
50% Tentamen | ||
|
50% Preparation tests | Tests at the start of each meeting | |
|
0% Hertentamen 1 |
We expect extensive preparation for nearly all of the meetings. We will test this at the start of each meeting and the test
results form 50% of your final grade. The meetings include for a large part group work on problems related to the studied materials.
The final exam will be based on a few physiological cases. Each case will contain a number of questions, ranging from the style seen in the entrance tests of the meeting (knowledge, understanding) to that of the group work questions (application, analysis) . We will provide example exams on BB and use the two last meetings to discuss these. The final exam counts for 50% of your grade.
The 'Regulations governing fraud and plagiarism for UvA students' applies to this course. This will be monitored carefully. Upon suspicion of fraud or plagiarism the Examinations Board of the programme will be informed. For the 'Regulations governing fraud and plagiarism for UvA students' see: www.uva.nl/plagiarism
|
meeting |
Where When |
Who |
What (Boron pages 3rd edition) |
|
1 |
Monday, Sept 04 WN-C659 |
Marcus |
Cardiac Electrophysiology · introduction of the course and intake test · Boron Ch 6, pgs 149-150; Ch 7 pgs 173-177; Ch 21: Cardiac Electrophysiology · Electrical model of cell membrane · Action Potential |
|
2 |
Thursday, Sept 07, WN-P647 |
van Bavel |
Fluid mechanics 1 · Boron Ch 17: Introduction Cardiovascular System (flow part) · Boron Ch 18: Blood · Boron Ch 19: Arteries and Veins (up to elastic properties) |
|
3 |
Monday, Sept 11, HG-14A36 |
van Bavel |
Fluid Mechanics 2 · Fluid mechanics: Navier-Stokes (document in BB) |
|
4 |
Thursday, Sept 14, |
Marcus |
The Heart as a Pump · Boron Ch 9: mechanics of muscle cells, pg 238 Muscle |
|
|
WN-P647 |
|
contractions.. until pg 240 including At higher load.. · Boron Ch 22: The heart as a pump · Pressure-Volume loops |
|
5 |
Monday, Sept 18, WN-S631 |
van Bavel |
Vascular Wall Mechanics · Boron Ch 19: Arteries and Veins / elastic properties · Introduction to wall mechanics (document in BB) |
|
6 |
Thursday, Sept 21, WN-P647 |
Marcus |
The Respiratory System · Boron Ch 26: Organization of the respiratory system · Boron Ch 27: Mechanics of ventilation |
|
7 |
Monday, Sept 25, WN-F637 |
Marcus |
Gas Exchange in the Lungs · Boron Ch 29 Transport of O2 and CO2 …, pg 642-~651; · Ch 30: Gas exchange in the lungs · Diffusion and perfusion effects on gas transport |
|
8 |
Thursday, Sept 28, WN-P647 |
van Bavel |
Wave Propagation and Reflection · Wave propagation and reflection (document in BB) |
|
9 |
Monday, Oct 02, WN-F607 |
van Bavel |
The Microcirculation · Boron Ch 20: The Microcirculation · Diffusion (document in BB) |
|
10 |
Thursday, Oct 05, WN-P647 |
Marcus |
Ventilation and Perfusion of the Lungs · Boron Ch 31: Ventilation and perfusion of the lungs · Pulmonary vascular pressure, resistance and compliance |
|
11 |
Monday, Oct 09, WN-C659 |
van Bavel |
Regulation of Arterial Pressure and Cardiac Output · Boron Ch 23: Regulation of arterial pressure and cardiac output · Boron Ch 25: Integrated control |
|
12 |
Thursday, Oct 12, WN-P647 |
Marcus |
Control of Ventilation · Boron ch 32: Control… |
|
13 |
Monday, Oct 16, WN-C659 |
Marcus |
Round-up of cardiac and pulmonary aspects of the course |
|
14 |
!!!!! |
van Bavel |
Round-up of vascular and integrated aspects of the course (availability issue, originally scheduled for Thursday, Oct 19, WN- P647 but we will announce an alternative) |
|
EXAM |
Tuesday, Oct 24, WN-Q105 8.45-11.30 |
You! |
PLEASE CHECK BB ANNOUNCEMENTS AND DATANOSE FOR POSSIBLE UPDATES ON TIME AND PLACE!!!! |
The vast majority of the meetings will be based on a specific subject within the scope of this course. Importantly, we expect you to have studied the relevant material before you come to the meeting. You will therefore need to heavily prepare for each meeting; this is not a ‘sit back and relax’ course with a tutor sweating over 200 powerpoint slides or endless mathematical derivations on the chalk board!
Rather, we will build each meeting on the following parts:
- We will start with a short entrance test, typically consisting of around 10 multiple choice questions. This test aims to probe whether you are sufficiently prepared, meaning that you know the facts and understand the meaning of the material. You will obviously do this test individually. The entrance tests are part of your Exam.
- After taking in the tests, we will give and discuss the answers should there be anything unclear.
- We will then address any questions you might have on the material. We strongly suggest that you mail your questions at 9.00 AM on the meeting day at the latest, so that we have some time to prepare their discussion.
- We then will commence group work: In groups of four persons, you will be addressing more complicated group exercises, generally at the level of application of your achieved knowledge and understanding. Some exercises are rather straightforward applications, some may have multiple approaches and answers, some may show to be too complex to handle and once and awhile, we also don’t know the answer…. The purposes of these exercises are to let you apply the material in a proactive and creative way, to provide perspective for the material, for instance as concerns relevance for cardiovascular diseases, and to train your skills as collaborator in groups. All groups will get the same questions and after each set we will compare and discuss the answers. This work is not part of your Exam but we do take the liberty to adjust your final grade (in either direction) on the basis of your attitude during this work. We will make a new grouping for each meeting.
In the first meeting we will among others introduce the course, arrange some logistics and make a start with cardiac electrophysiology; you do not have to prepare for this but we will also do some group work.
The last two meetings are reserved for reflection on the material, re-iteration of difficult subjects an discussion of example exam questions.
The schedule for this course is published on DataNose.
Recommended prior knowledge: In previous years students with Bachelor's in either physical or medical/biologic disciplines attended this course. We find the interaction between these students stimulating and of value for their training. However, a willingness to address both the mathematical/physical and medical/biological aspects is needed. To be able to succesfully follow this course, you should have a sufficient grasp of basic physics and mathematics, such as provided by Bachelor degrees in physics, engineering disciplines. Students with a background in medicine- and biology-related sciences should make sure that they have a sufficient background here.
We do not assume background knowledge in cardiovascular/respiratory physiology, but will maintain a high pace in introducing this during the course. Some background/interest in physiology therefore is quite helpful. Don't hesitate to contact the instructer for more information on this.
Max. participants: 30.