Pathology, Neurogenetics and Endocrinology

Course manual 2016/2017

Course content

The Experimental Internal Medicine track is unique because it is fully taught at an academic hospital, the Academic Medical Center (AMC). When you choose this track you will be exposed to a broad range of basic and applied clinical research and have the opportunity to meet top basic and clinical researchers working on a great variety of topics important for human health. It also serves as an excellent platform to explore internships and careers in biomedical research.

This course is divided in three parts. The topic of the first wo weeks is (neuro)endocrinology, in the next week you will learn about neurogenetics and the fourth week is reserved for the field of renal pathology and transplantation.

In all three subcourses you will be introduced to the current basic and clinical research themes of these three medical disciplines and will be immersed in state-of-the-art research in these areas.

The two weeks of (neuro)endocrinology will be focused on the endocrinological aspects of two large areas of biomedical research: energy metabolism and reproduction. Attention will be paid to the most current state of endocrinological insights in these areas, clinical expression of diseases therein, and to the experimental techniques and animal models used to unravel the biological underpinnings of normal and diseased states.

Central topics of the neurogenetics subcourse, will be nerve growth and repair of nerve injuries.

During the week reserved for renal pathology and transplantation, basic and clinical aspects of renal transplantation will be discussed in detail. This includes the study of in vitro and in vivo models of renal ischemia-reperfusion injury and repair, pathology of renal allograft rejection, immunosuppressive therapies and their complications, surgical procedures. Attention will be paid for the most state-of-the-art techniques and most recent scientific and clinical advances in this field.

Topics that will be covered in this course are broad and range from molecular biology, metabolism, immunology, functioning and interactions between our neural and endocrine systems to clinical treatment and (transplantation) surgery.

Study materials

Syllabus

• Scientific articles, Lectures (can be found on Blackboard)

Objectives

To learn about pathology, (neuro)endocrinology and neurogenetics and the relevance of these disciplines for human health and disease. Introduction to current issues in the basic and applied research that is performed to solve these issues. Meet top researchers and obtain hands on research experience in these fields.

After the course, the student should be able to:

• Identify different (neuro)endocrine systems
• Discuss the different types of renal transplantation rejection, the complications and opportunities of renal transplantation 
• Compare and select scientific technologies for specific applications
• Compile and clearly present a research proposal
• Interpret and clearly present scientific data.
• Collaborate with peers

Teaching methods

• Lecture
• Self-study
• Seminar
• Computer lab session/practical training
• Working independently on e.g. a project or thesis

Lectures will provide a state-of-the-art update on current issues in pathology, neurogenetics and (neuro)endocrinology. The writing of the essay and research proposal will help the student to critically interpret and present scientific data.

Learning activities

Attendance

The programme does not have requirements concerning attendance (OER-B).

Additional requirements for this course:

Additional requirements for this course:

Your presence at all course contents is obligatory.
We are willing to grant exemption when academic reasons prohibit attendance at times.

Assessment

Inspection of assessed work

The date, time and location of the inspection moment are in the DataNose timetable.

Assignments

Essay Neuroendocrinology

• Writing an essay on a given topic in groups (2-3 students).

Research Proposal Nephropathology

• Writing a research proposal on a given topic in groups (2-3 students).

Onderstaande opdrachten komen aan bod in deze cursus:

•    Naam opdracht 1 : beschrijving 2
•    Naam opdracht 2 : beschrijving 1
•    ....

Fraud and plagiarism

Dit vak hanteert de algemene ‘Fraude- en plagiaatregeling’ van de UvA. Onder plagiaat of fraude wordt verstaan het overschrijven van het werk van een medestudent dan wel het kopiëren van wetenschappelijke bronnen (uit bijvoorbeeld boeken en tijdschriften en van het Internet) zonder daarbij de bron te vermelden. Uiteraard is plagiaat verboden. Hier wordt nauwkeurig op gecontroleerd en streng tegen opgetreden. Bij verdenking van plagiaat wordt de examencommissie van de opleiding ingeschakeld. Wanneer de examencommissie overtuigd is dat er plagiaat gepleegd is dan kan dit maximaal leiden tot een uitsluiting van al het onderwijs van de opleiding voor een heel kalenderjaar. Zie voor meer informatie over het fraude- en plagiaatreglement van de Universiteit van Amsterdam.www.uva.nl/plagiaat

Course structure

Contact information

Coordinator

• A. Kalsbeek

Neuroendocrinology: A. Kalsbeek (a.kalsbeek@amc.uva.nl) / S. la Fleur (s.e.lafleur@amc.uva.nl)

Neurogenetics: F. Baas (f.baas@amc.uva.nl)

Nephropathology: S. Florquin (s.florquin@amc.uva.nl)