Neurodevelopment/Specification of Neuronal Systems

6 EC

Semester 1, period 1

5234NENS6Y

Owner Master Biomedical Sciences
Coordinator prof. dr. M.P. Smidt
Part of Master Biomedical Sciences, track Molecular Neurosciences,

Course manual 2025/2026

Course content

Topics/subjects:

  • Lectures in advanced neurodevelopment   
  • Lectures in neurodevelopment of the midbrain 
  • Practical course in midbrain development 
  • Bioinformatics course 
  • Expert guest speakers 
  • Journal clubs 
  • Meet the expert technology workshops

Subjects the student will master at the end of the course:

  • The molecular mechanisms underlying general neurodevelopment 
  • The molecular cascades underlying dopaminergic midbrain development 
  • How to design an experimental setup in order to investigate the role of a transcription factor in midbrain development 
  • How to integrate state of the art techniques and current knowledge into the formulation of a research question

Study materials

Syllabus

  • Study material and information will be provided at the course and will consist of a selection of excellent scientific papers published in international high-impact journals.

Objectives

  • distinguish and interpret neurodevelopmental processes.
  • criticize and evaluate scientific literature on neurodevelopmental processes.
  • independently design and execute an experiment in a laboratory.
  • evaluate experimental results (from a self designed experiment).
  • design, analyse and criticize an experiment (using bio-informatic tools).
  • interpret experimental results and present these in an oral presentation to a scientifically oriented public.
  • formulate a relevant research question about a neurological disease, using current literature and technology.
  • design an innovative and state-of-art research strategy.
  • to present a self designed research strategy, both in a written report and in an oral presentation, to a scientifically oriented public.

Teaching methods

  • Lecture
  • Seminar
  • Computer lab session/practical training
  • Presentation/symposium
  • Self-study
  • Working independently on e.g. a project or thesis
  • Supervision/feedback meeting

The courses will be both of theoretical and practical in nature. The student will attend lectures, perform experiments, critically evaluate literature, and give presentations covering the practical work and literature performed and discussed during the course. In addition an assignment covering all three courses will be completed.

Learning activities

Activity

Number of hours

Computerpracticum

8

Hoorcollege

44

Practicum

40

Tentamen

4

Werkcollege

24

Zelfstudie

4

Zelfstudie

44

Attendance

  • Some course components require compulsory attendance. If compulsory attendance applies, this will be indicated in the Course Catalogue which can be consulted via the UvA-website. The rationale for and implementation of this compulsory attendance may vary per course and, if applicable, is included in the Course Manual.
  • Assessment

    Item and weight Details

    Final grade

    1 (100%)

    Tentamen

    Fraud and plagiarism

    The 'Regulations governing fraud and plagiarism for UvA students' applies to this course. This will be monitored carefully. Upon suspicion of fraud or plagiarism the Examinations Board of the programme will be informed. For the 'Regulations governing fraud and plagiarism for UvA students' see: www.student.uva.nl

    Course structure

    Weeknummer Onderwerpen Studiestof
    1
    2
    3
    4
    5
    6
    7
    8

    Additional information

    A course in molecular biology and/or neurobiology is advised

    The maximum number of students is 20.

    Contact information

    Coordinator

    • prof. dr. M.P. Smidt